Accommodations along the Great River Road
in the Middle Mississippi River Valley

Guests to the Middle Mississippi River Valley region have a wide variety of Bed and Breakfast establishments as well as Guest Houses, Suites, and other forms of alternative lodging to choose from. The types of atmospheres of these establishments offer range from the elegant Victorian style, down home country charm, rustic outdoor adventure, and modern establishments meant for longer stays. In addition guests can choose to get away from it all in countryside settings or choose locations that are near the center of things. The area’s quality hotels and motels offer their guests a number of different lodging options in terms of price and location.


The Beall Mansion
An Elegant Bed & Breakfast Inn

407 E. 12th Street
Alton, IL

Voted “Best Illinois Bed and Breakfast” Inn—Illinois Magazine Readers Poll. Award winning accommodations along the Heartland Rivers Wine Trail. Private baths with shower and whirlpool for two or clawfoot tub, sumptuous triple sheeted feathered beds, complimentary Wi-Fi, HDTV, DVD, 24 hour “all you can eat” chocolate bar, and in room spa services by appointment.Check Availability & Rates.

Green Tree Inn
15 Mill Street
Elsah, IL

Enjoy the peacefulness of the Green Tree Inn, located in the heart of historic Elsah. Choose your room from five lovely spaces appointed to transport you to a place of serenity apart from the hustle and bustle of daily life that provides a relaxing atmosphere that reflects the peacefulness of historic Elsah. Check Availability & Rates.

Bed & Breakfasts


White Cliff Manor Bed & Breakfast
200 Second Street
St. Mary, MO

White Cliff Manor Bed & Breakfast and Gardens
Historic River Road Mansion
Spend your Ste. Genevieve Get away in Luxury
on the bluffs of the Mississippi River Valley
Luxurious Guest Rooms & Deluxe Breakfast Service
Along the Great River Road in Historic Ste. Genevieve County


Holiday Inn Club Vacations® Timber Creek Resort
4800 US Highway 67
De Soto, MO

Our beautiful resort sits on a 40-acre lake with a fishing dock and boat rentals. Discover a spacious two-bedroom villa complete with a fully equipped kitchen, dining area and living room. Plus, enjoy free parking and Wi-Fi. Resort amenities include a five-hole golf course, seasonal outdoor pool, movie theater, fitness center, an 18-hole mini golf course, activity center and more. Visit our website or call for more information.

Explore the Middle Mississippi River Valley