Welcome to the Middle Mississippi River Valley

The Great River Road is one of America’s national treasures. greatriverroad.com's coverage extends from the Keokuk, Iowa and Nauvoo, Illinois region to the areas in Missouri, past Southern Illinois where the Ohio River joins the Mississippi River, and through the Upper Delta region of Kentucky, Arkansas and Tennessee. greatriverroad.com brings our readers information on both the sides of the river from Illinois to western Tennessee on the eastern bank and Iowa to Arkansas on the western bank. Our coverage is divided into geographical regions that and brings you information on what to see and do, in-depth coverage of annual events, and where to shop, stay, and eat. We cover the history of real river towns and interesting facts to enhance your visit. Each region offers it visitors a different aspect of life along the Mississippi River whether it’s small town life, the big city atmosphere of the St. Louis metropolitan area, or the beginning of the Southern way of life. greatriverroad.com invites you to explore our pages and then to explore all the many regions and cultures of the Middle Mississippi River Valley.


Start Exploring by Region

A- The Tri-State Area
Iowa, Western Illinois, Northeastern Missouri
B- Missouri's Lincoln Hills
Northeastern Missouri
C- Meeting the Great Rivers Scenic Byway
Western Illinois
D -Meeting the Missouri River
St. Charles County, Missouri
E- Gateway to the West
Metropolitan St. Louis, Missouri
F- French Colonial Country
Eastern Missouri & Western Illinois
G- Meeting the Ohio River
Southeastern Missouri, Southern Illinois & Western Kentucky
H- The Upper Delta Region
Southeastern Missouri, Northeastern Arkansas & Western Tennessee


The Middle Mississippi River Valley region along the Great River Road offers its visitors a wealth of attractions and places of interest. Whether you are looking for historical sites, small town museums, unusual places of interest, arts and culture, or want to experience nature the Middle Mississippi River Valley has something you’re sure to be interested in. Visit the Attractions Index.


Lewis & Clark Historic Site
Hartford, Illinois


Saint Louis Zoo
St. Louis, Missouri


Reelfoot Lake State Park
Tiptonville, Tennessee


greatriverroad.com provides coverage of interesting events for a large area in the Middle Mississippi River Valley. Readers can explore these events using our calendars and what events interest them in communities in Illinois, Missouri, Iowa, Kentucky, Arkansas, and Tennessee. Visit the Events Cover Page.


American Indian Education Days
September 14 - 15, 2019
Collinsville, Illinois


Oktoberfest at Donau-Park
September 14 - 15, 2019
House Springs, Missouri


Greentree Festival
September 13 - 15, 2019
Kirkwood, Missouri


Mosaics Arts Festival
September 13 - 15, 2019
St. Charles, Missouri


Bootheel Regional Judged Art Show
Through September 28, 2019
Sikeston Depot Museum
Sikeston, Missouri
There are plenty of exceptional artists that live in the Bootheel region of Missouri. Every year the Sikeston Depot Museum and the Missouri Arts Council holds its annual Bootheel Regional Judged Art Show showcasing Sikeston area artists 18 years and up living within 75 miles of Sikeston.



The Art Trail
While researching the Great River Road area around St. Louis the editors of greatriverroad.com came across a surprisingly large number of festivals, galleries, museums, shops, and studios that involved the visual or performing arts. So much so that the decision was made to create a new section devoted to the art community of the Middle Mississippi River Valley. Most of the attractions and events on the greatriverroad.com art trail are within a few hours drive from St. Louis making an interesting way to spend an afternoon. The area covered is too large to spend exploring in one day so we suggest that you choose a region to concentrate on.


Lewis and William Clark in the Middle Mississippi River Valley
Captains Meriwether Lewis and William Clark reached the Middle Mississippi River Valley on November 20, 1803 and would use the region as a staging ground to prepare for the exploration of the Missouri River and the territory of the newly acquired Louisiana Purchase. On May 21st, 1804, the expedition set sail from St. Charles, Missouri into the relative unknown. The Middle Mississippi River Valley has an abundance of Lewis and Clark sites and events that offer visitors a unique glimpse into this exciting period of American history. greatriverroad.com has created this Lewis and Clark section to help visitors with special guides to these sites and events as well as additional articles on the various historical activities and aspects related to six months that Lewis and Clark spent in this region.


Bald Eagles
Bald Eagles live near large bodies of open water such as seacoasts, lakes and rivers where there are plenty of fish to eat and tall trees for roosting. There are approximately 2,000 eagles that migrate to the Middle Mississippi River Valley, making the region's overwintering population the second largest in the continental United States behind the Klamath Basin area of southern Oregon and northern California. The area's eagles come mainly from nesting territories in central Canada and the Great Lake states. When the water freezes up north the eagles migrate south to places like the Melvin Price Locks and Dam, the Alton Lake section of the Mississippi River, the Two Rivers National Wildlife Refuge, Pere Marquette State Park, and the Clarksville area where conditions are favorable. The first eagles are usually spotted in December and they migrate back north in March. See the Where to Watch for details on great eagle watching locations.

Things to Do

Complimenting Your Visit

Explore the Middle Mississippi River Valley